Clinton B. Mathias
Associate Professor of Pharmacology
Department of Pharmaceutical & Administrative Sciences
Office: CSP 325
Office Hours: By Appointment
Adjunct Assistant Professor
Department of Animal and Veterinary Sciences
University of Massachusetts at Amherst
High School Teachers Summer Research Program
American Association of Immunologists
Clinton Mathias received his B.Sc. in Microbiology and Biochemistry and M.Sc. in Microbiology from St. Xavier’s College, University of Mumbai, India. He received his Ph.D. in Biomedical Sciences (Immunology) from the University of Connecticut Health Center in Farmington, CT. Prior to joining Western New England University, Dr. Mathias was an Instructor at Harvard Medical School and an adjunct faculty member at the Massachusetts College of Pharmacy and Health Sciences. He also completed a post-doctoral fellowship at Boston Children’s Hospital, Harvard Medical School in the areas of mast cell biology, allergic inflammation, and asthma.
Dr. Mathias’ research has identified novel roles for IgE antibodies in the homeostasis of mast cells in experimental models of atopic and occupational asthma. He has studied the role of various immune cells such as natural killer cells in allergic inflammation and contributed to the study of diverse genetic and immune mechanisms underlying asthma. He has also developed models to investigate mechanisms of food allergy to orally ingested antigens. Dr. Mathias’ research has been funded by grants from the NIH. He has published several peer-reviewed articles and presented his work at regional, national, and international venues.
Immunology, Emerging Infectious Disease Elective, Respiratory IPC, Infectious Disease IPCs, Derm&Musculoskeletal IPC, Hematology/Oncology IPC
IgE antibodies and mast cells play well-established roles in the development of food allergy. Our lab is interested in the mechanisms by which mast cells mediate food and airway allergic responses in vivo, and the dynamics of mast cell interactions with other immune cell types during the development of allergic responses. Present projects in the lab include studying the ability of dietary substances to modulate the allergic response, assessing the effects of epigenetic modifications on the development of allergy, and investigation of the role of immunoregulatory cytokines in the development of asthma and food allergy.
Kinney S, Carlson L, Ser-Dolansky J, Shah S, Gambrah G, Thompson C, Xing W, Schneider SS and Mathias CB*. 2015. PLoS One. Jul 6;10(7):e0132467.
Mathias CB*. A Learner-Led, Discussion-based Elective on Emerging Infectious Disease. 2015; 79 (6) Article 81.). American Journal of Pharmaceutical Education.
Mathias CB. Natural killer cells in the development of asthma. 2015. Curr Allergy Asthma Rep. Feb;15(2):500.
Mathias CB*, Guernsey LA, Zammit D, Brammer C, Wu CA, Thrall RS, Aguila HL. Proinflammatory role of natural killer cells in allergic airway disease. 2014. Clinical and Experimental Allergy. 44(4):589-601.
Poddighe D, Mathias CB, Freyschmidt EJ, Kombe D, Caplan B, Marseglia GL, Oettgen HC. Basophils are rapidly mobilized following initial aeroallergen encounter in naïve mice and provide a priming source of IL-4 in adaptive immune responses. 2014. Journal of Biological Regulators and Homeostatic Agents. 28(1):91-103.
Rose L, Bias TE, Mathias CB, Trooskin SB, Fong JJ. Sofosbuvir: A Nucleotide NS5B Inhibitor for the Treatment of Chronic Hepatitis C Infection. 2014. Annals of Pharmacotherapy. 2014 May 8;48(8):1019-1029.
Freyschmidt EJ, Mathias CB, Diaz N, MacArthur DH, Laouar A, Manjunath N, Hofer MD, Wurbel MA, Campbell JJ, Chatila TA, Oettgen HC. Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses.2010. Journal of Immunology. Jul 15;185(2):1295-302. Epub 2010 Jun 14.
Tachdjian R, Mathias CB, Al Khatib S, Bryce PJ, Kim HS, Blaeser F, O'Connor BD, Rzymkiewicz D, Chen A, Holtzman MJ, Hershey GK, Garn H, Harb H, Renz H, Oettgen HC, Chatila TA. Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma. 2009. Journal of Experimental Medicine. 206(10):2191-204. Epub 2009 Sep 21.
Tachdjian R, Al Khatib S, Schwingshackl A, Kim HS, Chen A , Mathias CB, Kim HY, Umetsu D, Oettgen HC and Chatila TA. In vivo Regulation of the Allergic Response by the Interleukin 4 Receptor Alpha Chain Immunoreceptor Tyrosine-based Inhibitory Motif. 2009. Journal of Allergy and Clinical Immunology. 125(5):1128-1136.e8. Epub 2010 Apr 14.
Jin H, Oyoshi MK, Le Y, Bianchi T, Koduru S, Mathias CB, Kumar L, Le Bras S, Young D, Collins M, Grusby MJ, Wenzel J, Bieber T, Boes M, Silberstein LE, Oettgen HC, Geha RS. IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. 2009. Journal of Clinical Investigation. 119(1):47-60.
Jin H, Kumar L, Mathias CB, Oettgen HC, Gorelik L and Geha RS. Toll-like receptor 2 is important for the Th1 response to epicutaneous sensitization. 2009. Journal of Allergy and Clinical Immunology. 123(4):875-882.
Mathias CB, Freyschmidt EJ and Oettgen HC. IgE antibodies enhance pulmonary inflammation induced by inhalation of a chemical hapten. 2009. Clinical and Experimental Allergy. 39(3):417-25.
Mathias CB, Freyschmidt EJ, Caplan B, Jones T, Poddighe D, Xing W, Harrison KL, Gurish MF, Oettgen HC. IgE influences the number and function of mature mast cells but not progenitor recruitment in allergic pulmonary inflammation. 2009. Journal of Immunology. 182(4):2416-24.
Freyschmidt EJ, Mathias CB, MacArthur DH, Laouar A, Narasimhaswamy M, Weih F, and Oettgen HC. Skin inflammation in RelB-/- mice leads to defective immunity and impaired clearance of vaccinia virus. 2007. Journal of Allergy and Clinical Immunology .19(3):671-9.
Bryce PJ, Mathias CB, Harrison KL, Watanabe T, Geha RS and Oettgen HC. The H1 histamine receptor regulates allergic lung responses. 2006. Journal of Clinical Investigation. 116(6):1624-32.
Mehrotra S, Chhabra A, Chakraborty A, Chattopadhyay S, Slowik M, Stevens R, Zengou R, Mathias C, Butterfield LH, Dorsky DI, Economou JS, Mukherji B, Chakraborty NG. Antigen presentation by MART-1 adenovirus-transduced interleukin-10-polarized human monocyte-derived dendritic cells. 2004. Immunology. 113(4):472-81.