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Diptiman Bose

Diptiman BoseAssistant Professor of Pharmacology
Department of Pharmaceutical & Administrative Sciences

Email:     diptiman.bose@wne.edu
Phone:   413-796-2442
Office:    CSP 319


Research Interests 

My research focuses on investigating the impact of xenobiotics and pharmacological agents on ion channels and proteins involved in regulating cellular calcium homeostasis. The studies conducted will focus on two key calcium ion channels (a) plasma membrane calcium entry channels, the store operated calcium entry channels (SOCE) and (b) ligand-gated calcium release channel, the Ryanodine receptor. These calcium ion channels play a pivotal role in regulating critical cellular functions such as gene transcription, neurotransmitter release, immune cell regulation, cardiac and skeletal muscle contraction. Xenobiotics such as brominated flame retardants and polychlorinated biphenyls (PCBs) have been known to cause various endocrine, neurological and immunological deficits in humans. Although the mechanisms of toxicity are yet unknown, these agents are thought to dysregulate calcium homeostasis and calcium-dependent signaling pathways. The purpose of studies in my laboratory will be to identify and elucidate the underlying mechanisms of toxicity elicited by this class of xenobiotics and other environmental contaminants.


PROFESSIONAL EXPERIENCE 

   Assistant Project Scientist, 2010-2012, Department of Molecular Biosciences, School of Veterinary Sciences, University of California, Davis 


EDUCATION

   Postdoctoral scholar, 2006-2010, University of California, Davis,    
         Mentor: Dr. Isaac N Pessah
   Ph.D., Cellular Pharmacology, 2002-2006, University of the Pacific, Stockton, CA.
         Advisor: Dr. David W Thomas
   M.S, Cellular Pharmacology, 2000-2002, University of the Pacific, Stockton, CA.
         Advisor: Dr. David W Thomas
   B. Pharmacy 1994- 1998, University of Mumbai, Mumbai, India 


Referred Publications and Abstracts 

  • Waymen, A. G., Bose, D. D.*, Yang, D., Lesaik, A., Bruun, D., Impey, S., Ledoux, V., Pessah, N. I., Lein, P. J. (2012) PCB modulates calcium-dependent signaling pathway responsible for activity-dependent dendritic growth. Environmental Health Perspectives. 120 (7):1003-9 *Authors have contributed equally to this work.

  • Waymen, A. G., Yang, D., Bose, D. D., Lesaik, A., Bruun, D., Impey, S., Ledoux, V., Pessah, N. I., Lein, P. J. (2012) PCB95 promotes dendritic growth via Ryanodine receptor-dependent mechanisms. 120(7):997-1002. Environmental Health Perspectives.

  • Bose, D. D., Pessah, I. N. (2011). Ryanodine Receptors. UCSD-Nature Molecule Pages. doi:10.1038/mp.a002108.01.

  • Kim,K. H., Bose, D. D., Ghogha, A., Riehl, J., Zhang, R., Barnhart, C. D., Lein, P. J., Pessah, N. I. (2010) Para- and Ortho-Substitutions are Key Determinants of Polybrominated Diphenyl Ether Activity Toward Ryanodine Receptors and Neurotoxicity. Environmental Health Perspectives. 119 (4): 519-26

  • Thor, D., Zhang, R., Anderson, L., Bose, D. D., Dube, P. G., Rahimian, R. (2010) Effects of 17 β-estradiol on lippopolysaccharide-induced intracellular adhesion molecule-1 mRNA expression and Ca2+ homeostasis alteration in human endothelial cells.  Vascular Pharmacology. 53 (5-6); 230-8.

  • Barrientos, G., Bose, D. D, Feng, W., Padilla, I., Pessah, N. I. (2009). The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels. Molecular Pharmacology. 76 (3); 560-8. 

  • Bose, D. D., Thomas, W. D. (2008). The actin cytoskeleton differentially regulates NG115-401L cell ryanodine receptor and inositol 1,4,5-trisphosphate receptor induced calcium signaling pathways. Biochemical Biophysical Research Communications. 379 (2): 594-99.

  • Pessah, N. I., Lehmler, Robertson, L., Perez, C. F., Cabrales, E, Bose, D. D., and Feng, W. (2008). Enantiomeric specificity of (-)-2,2',3,3',6,6'-hexachlorobiphenyl toward ryanodine receptor types 1 and 2. Chemical Research in Toxicology. 22(1): 201-7.

  • Bose, D. D., Thomas, W. D. (2006). 2-Aminoethoxydiphenyl borate (2-APB) stimulates a conformationally coupled calcium release pathway in the NG115-401L neuronal cell line.  Neuropharmacology. 50(5): 532-9.

  • Padar, S., Bose, D. D., Livesy, J. C., Thomas, W. D. (2005). 2-Aminoethoxydiphenyl borate perturbs hormone-sensitive calcium stores and blocks store-operated calcium influx pathways independent of cytoskeletal disruption in human A549 lung cancer cells. Biochemical Pharmacology 69(8): 1177-86.


ABSTRACT PRESENTATIONS AND LECTURES

  • Bose, D. D, Eloi, M., Van de Water, J., Pessah, I. Society of Toxicology, San Francisco, March 2012

  • Bose, D. D, Invited lecture, Cell and Molecular biology techniques: Fluorescence based imaging techniques. TJL School of Pharmacy, University of the Pacific, Stockton.

  • Bose, D. D, Yang, D, Lein, P. J., Pessah, I. Society of Toxicology, Washington D.C. March 2011

  • Bose, D. D, Kaplan, E., Yang, D, Lein, P. J., Pessah, I. 26th International Neurotoxicology Conference, Portland 2010

  • Bose, D. D, Yang, D, Lein, P. J., Pessah, I. Society of Toxicology, Salt Lake City, March 2010

  • Bose, D. D, Barrientos, G., Yuen, B., Maxwell, S, Perez, C., Yamaguchi, N., Meissner, G., Allen, D. P., Pessah, I. Biophysical Society Meeting, San Francisco, 2010.

  • Bose, D. D, Perez C, Yamaguchi, N, Meissner, G, Allen, D. P., and Pessah, I.  Society of Toxicology, Seattle, March 2007.

  • Bose, D. D., Thomas W. D.  Experimental Biology, International Congress of Physiological Sciences, FASEB. San Diego, April 2005.

  • Bose, D. D., Rahimian, R., Thomas, W. D. American Society of Cell Biology San Francisco, December 2002.

  • Bose, D. D., Thomas, W. D.  World Congress of Pharmacology, ASPET meeting, San Francisco, July 2002.