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Shannon Kinney

Assistant Professor of Pharmacology
Department of Pharmaceutical & Administrative Sciences

Email:     shannon.kinney@wne.edu
Phone:   413-796-2439
Office:    CSP 322

Office Hours:  By Appointment


Education: 

   B.S. with honors in Environmental and Forest Biology from SUNY College of Environmental Science and Forestry (2002)
   Ph.D. in Pharmacology and Therapeutics from SUNY at Buffalo - Roswell Park Cancer Institute (2009)
   Post-doctoral fellowship in RNA Biology Division of  New England Biolabs, Inc. (2009-2012)


Classes Taught:

   Biochemistry, Endocrine/ Reproduction/ Genitourinary IPC, Oncology, From Bench to Bedside Elective, Principles of Genetics and Genomics, Hematology/ Oncology IPC


Research Interests: 

My research focuses on gene regulation at the transcriptional level, primarily DNA modifications, but also histone modifications.  Because this process is important in many different normal and disease specific processes I have several projects in my laboratory and with collaborators that cover a broad range of fields.  My major focus is cancer research, especially prostate cancer, with projects that examine the function of DNA hydroxymethylation in gene regulation and how this may be disrupted in cancer, as well as the identification of hypermethylated genes in prostate cancer that could potentially be used as biomarkers.  I also work on several collaborative projects with other members in the Department and scientists at Northeastern University.  These projects include epigenetic regulation of calcium signaling factors/channels and imunnoregulatory genes and the use of nanopores to study DNA:histone interactions.


Recent Publications:

A. Book Chapters

  1. Morey Kinney, Shannon and Sriharsa Pradhan. Ten Eleven Translocation (TET) Enzymes and 5-Hydroxymethylation inCancer.  Epigenetic Alterations in Oncogenesis (Springer), Edited by Dr. Adam Karpf. In press.

  2. Morey Kinney, Shannon and Sriharsa Pradhan. Regulation of Expression and Activity of DNA (cytosine-5) methyltransferases in mammalian cells. Prog Mol Biol Transl Sci. 2011;101:311-33.

B. Journal Articles

  1. Kinney S.R., Carlson L, Ser-Dolansky J, Thompson C, Shah S, Gambrah A, Xing W, Schneider S.S., Mathias C.B. Curcumin Ingestion Inhibits Mastocytosis and Suppresses Intestinal Anaphylaxis in a Murine Model of Food Allergy. PLoS One. 2015 Jul 6;10(7):e0132467.

  2. Langecker M., A. Ivankin , S. Carson, S.R. Kinney, F.C. Simmel, M Wanunu. Nanopores suggest a negligible influence of CpG methylation on nucleosome packaging and stability. Nano Lett. 2015 Jan 14;15(1):783-90.

  3. Ivankin, Andrey, Spencer Carson, Shannon R. M. Kinney, and Meni Wanunu. Fast, Label-Free Force Spectroscopy of Histone-DNA Interactions in Individual Nucleosomes Using Nanopores. J Am Chem Soc. 2013 Oct 16;135(41):15350-2.

  4. Morey Kinney, Shannon*, Hang Gyeong Chin*, Romualdas Vaisvila, Jurate Bitinaite, Yu Zheng, Pierre Olivier Esteve, Suhua Feng, Hume Stroud, Steven E. Jacobsen and Sriharsa Pradhan. Tissue Specific Distribution and Dynamic Changes of 5-hydroxymethylcytosine in Mammalian Genomes. J Biol Chem. 2011 Jul 15;286(28):24685-93. Highly Accessed  *Equal contribution

  5. Morey Kinney, Shannon R., Michael T. Moser, Marien Pascual, John M. Greally, Barbara A. Foster, and Adam R.Karpf. Opposing roles of Dnmt1 in early and late stage murine prostate cancer. Mol Cell Biol. 30(17):4159-74. September 2010


Hobbies and Interests: 

   Hiking, gardening, reading, cooking, spending time with my family and pets.