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Faculty

Clinton B. Mathias

Professor of Pharmacology | Program Coordinator of Masters in Pharmaceutical Sciences
Office: CSP 325
413-796-2414

Clinton Mathias received his B.Sc. in Microbiology and Biochemistry and M.Sc. in Microbiology from St. Xavier’s College, University of Mumbai, India. He received his Ph.D. in Biomedical Sciences (Immunology) from the University of Connecticut Health Center in Farmington, CT. Prior to joining Western New England University, Dr. Mathias was an Instructor at Harvard Medical School and an adjunct faculty member at the Massachusetts College of Pharmacy and Health Sciences. He also completed a post-doctoral fellowship at Boston Children’s Hospital, Harvard Medical School in the areas of mast cell biology, allergic inflammation, and asthma. In addition to his appointment at the College of Pharmacy and Health Sciences, Dr. Mathias is also an Adjunct Associate Professor in the Department of Veterinary and Animal Sciences at the University of Massachusetts at Amherst. 

Dr. Mathias’ research has identified novel roles for IgE antibodies in the homeostasis of mast cells in experimental models of atopic and occupational asthma. He has studied the role of various immune cells such as mast cells and natural killer cells in allergic inflammation and contributed to the study of genetic and immune mechanisms underlying food allergy and asthma.  Dr. Mathias’ research has been funded by grants from the NIH. He has published several peer-reviewed articles and presented his work at regional, national, and international venues.

INTERESTS

IgE antibodies and mast cells play well-established roles in the development of food allergy. Our lab is interested in the mechanisms by which mast cells mediate food and airway allergic responses in vivo, and the dynamics of mast cell interactions with other immune cell types during the development of allergic responses. Present projects in the lab include studying the ability of dietary substances to modulate the allergic response, assessing the effects of epigenetic modifications on the development of allergy, and investigation of the role of immunoregulatory cytokines in the development of asthma and food allergy.

COURSES TAUGHT

PHAR 522 Immunology

PHAR 651 Emerging Infectious Disease Elective

PHAR 622 Respiratory Integrated Pharmacy Module

PHAR 713 Infectious Disease Integrated Pharmacy Course

Derm&Musculoskeletal Integrated Pharmacy Course

PUBLICATIONS

Books

Mathias, McAleer, and Szollosi: Pharmacology of Immunotherapeutic Drugs, Springer Nature Publishing Company Website: https://www.springer.com/us/book/9783030199210#aboutBook

Book Chapters

Mathias CB*. Overview of the Immune System and its Pharmacological Targets. In: Mathias CB, McAleer JP, Szollosi DE, editors. Pharmacology of Immunotherapeutic Drugs. Springer International Publishing 2020. p. 1-42.

Szollosi D and Mathias CB. Modulation of the Innate Immune System. In: Mathias CB, McAleer JP, Szollosi DE, editors. Pharmacology of Immunotherapeutic Drugs. Springer International Publishing 2020. p. 43-66.

Szollosi D, Mathias CB, and McAleer J. Modulation of the Adaptive Immune System. In: Mathias CB, McAleer JP, Szollosi DE, editors. Pharmacology of Immunotherapeutic Drugs. Springer International Publishing 2020. p. 67-98.

Mathias CB*. Respiratory Disorders of the Immune System and its Pharmacological Targets. In: Mathias CB, McAleer JP, Szollosi DE, editors. Pharmacology of Immunotherapeutic Drugs. Springer International Publishing 2020. p. 99-140.

Mathias CB*. Inflammation of the Skin and its Therapeutic Targets. In: Mathias CB, McAleer JP, Szollosi DE, editors. Pharmacology of Immunotherapeutic Drugs. Springer International Publishing 2020. p. 141-174.

Mathias CB*, McAleer J, and Szollosi D. Inflammatory Diseases of the Gastrointestinal Tract and Pharmacological Treatments. In: Mathias CB, McAleer JP, Szollosi DE, editors. Pharmacology of Immunotherapeutic Drugs. Springer International Publishing 2020. p. 175-205.

Mathias CB* and McAleer J. Transplantation: Immunologic Principles and Pharmacologic Agents. In: Mathias CB, McAleer JP, Szollosi DE, editors. Pharmacology of Immunotherapeutic Drugs. Springer International Publishing 2020. p. 251-276.

Szollosi D, Mathias CB, Lucero V, Ahmad S, Donato J. Immunopathogenesis, Immunization, and Treatment of Infectious Diseases. In: Mathias CB, McAleer JP, Szollosi DE, editors. Pharmacology of Immunotherapeutic Drugs. Springer International Publishing 2020. p. 277-319.

Journal Articles

Krajewski D, Polukort SH, Gelzinis J, Rovatti J, Kaczenski E, Galinski C, Pantos M, Shah NN, Schneider SS, Kennedy DR and Mathias CB. (2020 ). Protein disulfide isomerases regulate IgE-mediated mast cell responses and their inhibition confers protective effects during food allergy development. . Frontiers in Immunology

Krajewski D, Kaczenski E, Rovatti J, Polukort S, Thompson C, Dollard C, Ser-Dolansky J, Schneider SS, Kinney SRM, Mathias CB (2018 , November ). Epigenetic Regulation via Altered Histone Acetylation Results in Suppression of Mast Cell Function and Mast Cell-Mediated Food Allergic Responses. . Frontiers in Immunology ,9 , 2414.

Thangam EB, Jemima AE, Singh H, Bag MS, Khan M, Mathias CB, Church MK and Saluja R (2018 , August ). The role of histamine and histamine receptors in mast cell-mediated allergy and inflammation: the hunt for new therapeutic targets. . Frontiers in Immunology ,9

Poddighe D, Mathias CB, Brambilla I, Marseglia GL, Oettgen HC. (2018 ). Importance of basophils in eosinophilic asthma: the murine counterpart. . J Biol Regul Homeost Agents. ,32 , 335.

Mathias CB*, Schramm CM, Guernsey LA, Wu CA, Polukort SH, Rovatti J, Ser-Dolansky J, Secor E, Schneider SS, Thrall RS, Aguila HL. (2017 ). IL-15-deficient mice develop enhanced allergic responses to airway allergen exposure. . Clinical and Experimental Allergy

Polukort SH, Rovatti J, Carlson L, Thompson C, Ser-Dolansky J, Kinney SRM, Schneider SS and Mathias CB (2016 ). IL-10 Enhances IgE-Mediated Mast Cell Responses and Is Essential for the Development of Experimental Food Allergy in IL-10–Deficient Mice. . Journal of Immunology

Kinney S, Carlson L, Ser-Dolansky J, Shah S, Gambrah G, Thompson C, Xing W, Schneider SS and Mathias CB*. Curcumin Ingestion Inhibits Mastocytosis and Suppresses Intestinal Anaphylaxis in a Murine Model of Food Allergy. 2015. PLoS One. Jul 610(7):e0132467.

Mathias CB (2015 , February ). Natural killer cells in the development of asthma . Curr Allergy Asthma Rep ,15 , 500.

Mathias CB (2015 ). A Learner-Led, Discussion-based Elective on Emerging Infectious Disease . American Journal of Pharmaceutical Education ,79

Rose L, Bias TE, Mathias CB, Trooskin SB, Fong JJ (2014 , May ). Sofosbuvir: A Nucleotide NS5B Inhibitor for the Treatment of Chronic Hepatitis C Infection . Annals of Pharmacotherapy ,48 , 1019-1029.

Mathias CB, Guernsey LA, Zammit D, Brammer C, Wu CA, Thrall RS, Aguila HL (2014 ). Proinflammatory role of natural killer cells in allergic airway disease . Clinical and Experimental Allergy ,44 , 589-601.

Poddighe D, Mathias CB, Freyschmidt EJ, Kombe D, Caplan B, Marseglia GL, Oettgen HC (2014 ). Basophils are rapidly mobilized following initial aeroallergen encounter in naïve mice and provide a priming source of IL-4 in adaptive immune responses . Journal of Biological Regulators and Homeostatic Agents ,28 , 91-103.

Freyschmidt EJ, Mathias CB, Diaz N, MacArthur DH, Laouar A, Manjunath N, Hofer MD, Wurbel MA, Campbell JJ, Chatila TA, Oettgen HC (2010 , July ). Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses . Journal of Immunology ,185 , 1295-302.

Tachdjian R, Mathias CB, Al Khatib S, Bryce PJ, Kim HS, Blaeser F, O'Connor BD, Rzymkiewicz D, Chen A, Holtzman MJ, Hershey GK, Garn H, Harb H, Renz H, Oettgen HC, Chatila TA (2009 ). Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma . ournal of Experimental Medicine ,206 , 2191-204.

Tachdjian R, Al Khatib S, Schwingshackl A, Kim HS, Chen A , Mathias CB, Kim HY, Umetsu D, Oettgen HC and Chatila TA (2009 ). In vivo Regulation of the Allergic Response by the Interleukin 4 Receptor Alpha Chain Immunoreceptor Tyrosine-based Inhibitory Motif . Journal of Allergy and Clinical Immunology ,125 , 1128-1136.

Jin H, Oyoshi MK, Le Y, Bianchi T, Koduru S, Mathias CB, Kumar L, Le Bras S, Young D, Collins M, Grusby MJ, Wenzel J, Bieber T, Boes M, Silberstein LE, Oettgen HC, Geha RS (2009 ). IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice . Journal of Clinical Investigation ,119 , 47-60.

Jin H, Kumar L, Mathias CB, Oettgen HC, Gorelik L and Geha RS (2009 ). Toll-like receptor 2 is important for the Th1 response to epicutaneous sensitization . Journal of Allergy and Clinical Immunology ,123 , 875-882.

Mathias CB, Freyschmidt EJ and Oettgen HC (2009 ). IgE antibodies enhance pulmonary inflammation induced by inhalation of a chemical hapten . Clinical and Experimental Allergy ,39 , 417-25.

Mathias CB, Freyschmidt EJ, Caplan B, Jones T, Poddighe D, Xing W, Harrison KL, Gurish MF, Oettgen HC (2009 ). IgE influences the number and function of mature mast cells but not progenitor recruitment in allergic pulmonary inflammation . Journal of Immunology ,182 , 2416-24.

Freyschmidt EJ, Mathias CB, MacArthur DH, Laouar A, Narasimhaswamy M, Weih F, and Oettgen HC (2007 ). Skin inflammation in RelB-/- mice leads to defective immunity and impaired clearance of vaccinia virus . Journal of Allergy and Clinical Immunology ,19 , 671-9.

Bryce PJ, Mathias CB, Harrison KL, Watanabe T, Geha RS and Oettgen HC (2006 ). The H1 histamine receptor regulates allergic lung responses . Journal of Clinical Investigation ,116 , 1624-32.

Mehrotra S, Chhabra A, Chakraborty A, Chattopadhyay S, Slowik M, Stevens R, Zengou R, Mathias C, Butterfield LH, Dorsky DI, Economou JS, Mukherji B, Chakraborty NG (2004 ). Antigen presentation by MART-1 adenovirus-transduced interleukin-10-polarized human monocyte-derived dendritic cells . Immunology ,113 , 472-81.