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Diptiman Bose

Associate Professor of Pharmacology
Postdoctoral scholar, University of California, Davis
Ph.D., Cellular Pharmacology, University of the Pacific, Stockton, CA
M.S, Cellular Pharmacology, University of the Pacific, Stockton, CA
B. Pharmacy, University of Mumbai, Mumbai, India
Registered Pharmacist, MA,
Office: CSP 319

Laboratory Research

My current research interests focus is on investigating the impact of xenobiotics and pharmacological agents on ion channels and proteins involved in regulating cellular calcium homeostasis. The studies conducted will focus on two key calcium ion channels (a) plasma membrane calcium entry channels, the store-operated calcium entry channels (SOCE), and (b) ligand-gated calcium release channel, the Ryanodine receptor. These calcium ion channels play a pivotal role in regulating critical cellular functions such as gene transcription, neurotransmitter release, immune cell regulation, cardiac and skeletal muscle contraction. Persistent environmental pollutants such as brominated flame retardants and polychlorinated biphenyls (PCBs) have been known to cause various endocrine, neurological and immunological deficits in humans. Although the mechanisms of toxicity are yet unknown, these agents are thought to dysregulate calcium homeostasis and calcium-dependent signaling pathways. The purpose of studies in my laboratory will be to identify and elucidate the underlying mechanisms of toxicity elicited by this class of xenobiotics and other environmental contaminants. I am also interested in studying pharmacological agents that modulate calcium handling and regulation. We have investigated the effects of several compounds such as polyphenolic compounds such as Ellagic acid and gingerol on modulating the immune response.

Teaching and Learning

I am interested in studying the effectiveness of tools that lead to improved metacognition. I have employed and experimented with various teaching methodologies based on best practices in teaching and learning to enhance the classroom learning experience. Currently, we are studying the effect of strategies such as flowcharts, note-taking, and the use of High Fidelity simulation as learning tools.


Book Chapters

Bose, D. D (2017). Store Operated Calcium Entry channels: Potential role in Cardiac Function . In A. Malhotra and S. Soni (Eds.), Recent advances in Cardiovascular Diseases : IGI Global.

Zhou, Bose, D. D., Allen, P.D., and Pessah, I.N. (2013). Hereditary Neuromuscular Diseases and Malignant Hyperthermia. . In (Eds.), Miller’s Anesthesia : Churchill Livingstone, Phil. PA..

Journal Articles

Murphy, M., Qin, X., Kaul., S, Barrientos, G, Zou, Z Mathias, C.,Thomas, D., Bose, D. D. (2020 ). The polyphenol Ellagic Acid exerts anti-inflammatory actions via disruption of store-operated calcium entry (SOCE) pathway activators and coupling mediators. . European Journal of Pharmacology ,875

Bose, D.D, Murphy, M, Polidoro, J., Sun, S (2020 ). One drug, many uses: a narrative review of magnesium sulfate for Pharmacists . EC: Pharmacology and Toxicology

Wang, B., Zhang, J.,Chen, C., Xu, G.,Qin, X., Hong, Y, Bose, D. D, Qui, F., Zou, Z. (2018 ). The size of zinc nanoparticles controls its toxicity through imparing autophagic flux in A549 lung epithelial cells. . Toxicological Letters ,285 , 51-59.

Jiang, X, Tang, Q, Zhang, J., Wang, H., Bai, L., Meng, P., Qin, X., Bose, D. D, Wang, B., Chen, C., Zou, Z (2018 ). Autophagy-dependent release of zinc ions is critical for acute lung injury triggered by zinc oxide nanoparticles. . Nanoparticles ,12 , 1068-91.

Zhang, J., Qin, X., Wang, B., Qin, Z., Wang, J., Wu, L., Ju, X., Bose, D. D, Qui, F., Zhou, H., Zou, Z. (2017 , July ). The size of zinc nanoparticles controls its toxicity through imparing autophagic flux in A549 lung epithelial cells. . Cell Death and Differentiation ,8

(2016 ). An electrophysiology course for Pharmacy learners . American Journal of Pharmaceutical Education ,80

Zhang, C, Bose, D.D, Thomas, D. (2015 ). Paradoxical effects of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activator gingerol on NG115-401L neuronal cells: Failure to augment ER Ca2+ uptake and protect against ER stress-induced cell death. . European Journal of Pharmacology ,762 , 165-173.

Yang, D., kaina-Corwell, I., Ghogha, A., Chen, K., Stamu, M., Bose, D.D., Pessah, N. I., Lehmler, J. Lein, P. J. (2013 ). PCB 136 Atropselectively Alters Morphometric and Functional Parameters of Neuronal Connectivity in Cultured Rat Hippocampal Neurons via Ryanodine Receptor-Dependent Mechanisms. . Toxicological Sciences. ,138 , 379-92.

Bose, D. D (2013 ). Probiotics for recurrent Clostridium difficile infection in solid organ transplant recipients. Infectious diseases in clinical practice. . Infectious Disease in Clinical Practice ,9 , 221.

Waymen, A. G., Bose, D. D., Yang, D., Lesaik, A., Bruun, D., Impey, S., Ledoux, V., Pessah, N. I., Lein, P. J. (2012 ). PCB modulates calcium-dependent signaling pathway responsible for activity-dependent dendritic growth. . Environmental Health Perspectives

Waymen, A. G., Yang, D., Bose, D. D., Lesaik, A., Bruun, D., Impey, S., Ledoux, V., Pessah, N. I., Lein, P. J. (2012 ). PCB95 promotes dendritic growth via Ryanodine receptor-dependent mechanisms. . Environmental Health Perspectives

Bose, D. D., Pessah, I. N. (2011 ). Ryanodine Receptors. . UCSD-Nature Molecule Pages

Kim,K. H., Bose, D. D., Ghogha, A., Riehl, J., Zhang, R., Barnhart, C. D., Lein, P. J., Pessah, N. I. (2010 ). Para- and Ortho-Substitutions are Key Determinants of Polybrominated Diphenyl Ether Activity Toward Ryanodine Receptors and Neurotoxicity. . Environmental Health Perspectives

Thor, D., Zhang, R., Anderson, L., Bose, D. D., Dube, P. G., Rahimian, R. (2010 ). Effects of 17 β-estradiol on lippopolysaccharide-induced intracellular adhesion molecule-1 mRNA expression and Ca2+ homeostasis alteration in human endothelial cells. . Vascular Pharmacology

Barrientos, G., Bose, D. D, Feng, W., Padilla, I., Pessah, N. I. (2009 ). The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels. . Molecular Pharmacology

Bose, D. D., Thomas, W. D. (2008 ). The actin cytoskeleton differentially regulates NG115-401L cell ryanodine receptor and inositol 1,4,5-trisphosphate receptor induced calcium signaling pathways. . Biochemical Biophysical Research Communications

Pessah, N. I., Lehmler, Robertson, L., Perez, C. F., Cabrales, E, Bose, D. D., and Feng, W. (2008 ). Enantiomeric specificity of (-)-2,2',3,3',6,6'-hexachlorobiphenyl toward ryanodine receptor types 1 and 2. . Chemical Research in Toxicology

Bose, D. D., Thomas, W. D. (2006 ). 2-Aminoethoxydiphenyl borate (2-APB) stimulates a conformationally coupled calcium release pathway in the NG115-401L neuronal cell line. . Neuropharmacology

Padar, S., Bose, D. D., Livesy, J. C., Thomas, W. D. (2005 ). 2-Aminoethoxydiphenyl borate perturbs hormone-sensitive calcium stores and blocks store-operated calcium influx pathways independent of cytoskeletal disruption in human A549 lung cancer cells. . Biochemical Pharmacology